B. Ross, Mingming Han, V. Ravikumar
Aug 1, 2006
Citations
0
Influential Citations
5
Citations
Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
An efficient process to synthesize 5′-O-dimethoxytrityl-N4-benzoyl-5-methyl-2 ′-deoxycytidine in high yield and quality is described. Final benzoylation was improved by developing a method to selectively hydrolyze benzoyl ester impurities. This inexpensive approach was scaled up to multi-kilogram quantities for routine use in oligonucleotide therapeutics.