Michel Couturier, Brian M. Andresen, J. Jorgensen
2002
Citations
0
Influential Citations
18
Citations
Journal
Organic Process Research & Development
Abstract
An efficient four-step sequence has been developed for the synthesis of 3,4-isopropylidenedioxypyrrolidine hydrotosylate starting from inexpensive N-benzylmaleimide. This approach features a novel N-debenzylation procedure that utilizes the corresponding borane−benzylamine complex as an internal hydrogen-transfer source. This palladium-catalyzed tandem protonolysis/hydrogenolysis allows cleavage of the borane−amine adduct and debenzylation in a single operation.