Chen Xiaoyan
2011
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Journal
Chinese Journal of Pharmaceutical Analysis
Abstract
Objective:To develop an LC-UV/MS method for analysis of impurities of griseofulvin.Methods:Reversed-phase gradient chromatography was used to separate griseofulvin solution,which was detected by UV detector.The major impurities were identified by ion trap mass spectrometry equipped with ESI source in the positive ion mode.Results:Six impurities of griseofulvin,including dechlorgriseofulvin,dehydrogriseofulvin,isogriseofulvin,griseofulvic acid,4-demethylgriseofulvin and 6-demethylgriseofulvin were identified.Conclusion:The new developed method for the analysis of the related impurities in griseofulvin is useful to control the quality of griseofulvin.