C. Takahashi, A. Numata, E. Matsumura
Nov 25, 1994
Citations
3
Influential Citations
60
Citations
Quality indicators
Journal
The Journal of antibiotics
Abstract
Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells.