E. Bajusz
Jul 26, 1969
Citations
1
Influential Citations
17
Citations
Journal
Nature
Abstract
CALCIUM cyclamate is widely used as a sweetening agent in foods and beverages. We now find that oral administration of calcium cyclamate to hamsters induces myocardial lesions accompanied by coronary sclerosis as well as soft-tissue calcification in other organs. This adverse effect of calcium cyclamate overdosage remained unnoticed in earlier toxicological tests1–3 and it seems from our present studies that cyclamate may enhance the potentially toxic actions of the cation with which it forms a stable, water-soluble salt.