F. Dantas, M. O. Moraes, E. Carvalho
Oct 1, 1996
Citations
3
Influential Citations
56
Citations
Quality indicators
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Abstract
Stannous chloride (SnCl2) has been widely used in nuclear medicine as a reducing agent of pharmaceutical products radiolabelled with technetium-99m. To verify whether the lethality induced by this salt could be mediated by reactive oxygen species (ROS), Escherichia coli cultures were treated with SnCl2 in the presence of catalase, ROS scavengers or metal-ion chelators. The inactivation effect, as measured by survival determination, was abolished by thiourea, sodium benzoate, dipyridyl or catalase. The results suggest the participation of ROS, generated by a Fenton-like reaction, in the lethal effect induced by SnCl2.