Jing Han, Huan‐Huan Zhang, Peng‐Fei Xu
Oct 10, 2016
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0
Influential Citations
48
Citations
Journal
Organic letters
Abstract
A catalytic [3 + 1]-annulation reaction between cyclopropane 1,1-diester and aromatic amine is developed based on the relay catalysis strategy. Lewis acid-catalyzed nucleophilic ring opening of cyclopropane 1,1-diester with aromatic amine and (hypo)iodite-catalyzed C-N bond formation are combined successfully in one reaction. Using this reaction, biologically important azetidines and tetrahydroquinolines can be prepared directly.