A. Metzger, Matthias A. Schade, P. Knochel
Feb 21, 2008
Citations
1
Influential Citations
110
Citations
Quality indicators
Journal
Organic letters
Abstract
In the presence of zinc dust (1.5-2.0 equiv) and LiCl (1.5-2.0 equiv), various benzylic chlorides bearing functional groups (iodide, cyanide, ester, ketone) are smoothly converted at 25 degrees C to the corresponding zinc reagents without homo-coupling (<5%). The utility of these benzylic zinc reagents is demonstrated by a short synthesis of papaverine.