Hu Li, Gui-Xin Cai, Zhangjie Shi
Oct 27, 2010
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0
Influential Citations
84
Citations
Quality indicators
Journal
Dalton transactions
Abstract
Palladium-catalyzed highly regioselective carbonylation of substituted N,N-dimethylbenzylamines with the assistance of LiCl was developed. The ortho-functionalized N,N-dimethylbenzylamine was further transformed into ortho-methyl benzoate under mild conditions. These two transformations could be combined into one pot to produce the desired product in moderate yield. Applications of this methodology to synthesize the fragments of variolaric acid were also studied.