L. Chiummiento, M. Funicello, P. Lupattelli
Jul 17, 2012
Citations
0
Influential Citations
11
Citations
Journal
Organic letters
Abstract
An effective ligand-free Suzuki coupling protocol to unite methyl (E)-4-bromobut-2-enoate with several arylboronic acids has been accomplished. Thus, a number of variously functionalized methyl 4-arylcrotonates have been achieved in high to excellent yields under mild conditions. This method enables the preparation of diverse aryl-substituted cores of HIV-1 protease inhibitors.