B. Juskowiak, M. Ohba, Masao Satō
Feb 15, 1999
Citations
0
Influential Citations
21
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
A series of bis[2-(alkylpyridinium-4-yl)vinyl]benzene ligands has been prepared and characterized, and their interactions with DNA have been studied by a combination of spectroscopic, hydrodynamic, and biochemical methods. Although bis[2-(1-alkylpyridinium-4-yl)vinyl]benzene ligands interact with DNA by both groove binding and the intercalation mode, the resulting complexes have different binding characteristics, depending on the nature of the DNA. Unexpectedly, nonplanar E,Z isomer also binds to DNA with binding features resembling those of the E,E isomer, though with lower affinity. The interaction of both isomers with a minor groove of [poly(dA-dT)]2 resulted in the formation of more stable complexes compared to the intercalation complexes formed with [poly(dG-dC)]2. Small differences in the binding parameters between planar E,E and non-planar E,Z isomers were explained in terms of an incomplete insertion of a dye molecule in the minor groove (AT polymer) or intercalation pocket (GC polymer), thus allo...