A. Kamal, G. Khanna, T. Krishnaji
Sep 1, 2007
Citations
0
Influential Citations
11
Citations
Journal
Helvetica Chimica Acta
Abstract
Enzymatic resolution of racemic 3-hydroxy-4-(tosyloxy)butanenitrile ((� )-5) by using various lipases in different solvents were studied. The obtained optically pure (3R)-3-(acetyloxy)-4-(tosyloxy)butanenitrile ((R)-6), upon treatment with aqueous ammonia followed by conc. HCl solution, provided (R)-GABOB (¼ (3R)-4-amino-3-hydroxybutanoic acid; (R)-1). Similarly, reaction of (R)-6 with aqueous trimethylamine solution followed by conc. HCl solution provided (R)-carnitine hydrochloride (¼ (2R)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride; (R)-2 · HCl) in an expeditious manner.