Oliver Torre, V. Gotor‐Fernández, V. Gotor
Mar 6, 2006
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract The enzymatic resolution of 3-amino-3-phenylpropan-1-ol derivatives has been studied through acylation processes. Candida antarctica lipase A (CAL-A) has been identified as the best biocatalyst for the transesterification reaction of 3-amino-3-phenyl-1- tert -butyldimethylsilyloxy-propan-1-ol using ethyl methoxyacetate as acylating agent and tert -butyl methyl ether as solvent. This enzymatic study has allowed us to obtain a valuable intermediate for the production of ( S )-dapoxetine, which has been synthesized in good overall yield and high enantiomeric excess.