A. Kamal, T. Krishnaji, M. N. A. Khan
Jul 1, 2008
Citations
0
Influential Citations
5
Citations
Journal
Journal of Molecular Catalysis B-enzymatic
Abstract
Abstract Lipase-catalyzed resolution of 1-chloro-3-[(4-morpholin-4-yl-1,2,5-thiadiazole-3-yl)oxy]propan-2-ol (5) is described using vinyl acetate as acyl donor. The effect of different lipases from various sources in several solvents has been studied. This intermediate 5 is utilized in the preparation of enantiomerically enriched (R) and (S)-timolol.