T. Yokomatsu, Nobuko Nakabayashi, Koji Matsumoto
Dec 1, 1995
Citations
1
Influential Citations
17
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract A kinetic resolution of cis-1-diethylphosphonomethyl-2-hydroxymethylcyclohexane1 by lipase has been developed. The transesterification of (±)− 1 with vinyl acetate in the presence of Lipase AK without solvent proceeded to give (+)−1 and the corresponding acetate (+)−5 in good yield and high enantiomeric ratio. The alcohol (+)−1 was transformed to the optically active hydantoins 12 and 13, possible intermediates for the synthesis of conformational constrained analogues of AP-5.