K. Yamauchi, K. Togawa, M. Kinoshita
Jul 1, 1993
Citations
0
Influential Citations
4
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
1,2-Bis(dihydrophytyl)glycero-3-phosphate (DPhyPA) was synthesized as an analog of archaebacterial lipids. Upon sonicating in amine-containing buffers like 0.05 M Tris–HCl (pH 7.8), the lipid gave rise to the stable liposomal assemblies, which could store 5(6)-carboxyfluorescein at high temperature as high as 70 °C in the interior. The assembly also had a large negative zeta-potential and showed an absence of gel-to-liquid crystalline phase transition from −20 to 80 °C. A Langmuir monolayer at an air/water interface suggested that the maximum molecular area of the lipid was 0.9—1.0 nm2. These properties were compared with the assemblies prepared from conventional 1,2-dipalmitoyl-sn-glycero-3-phosphate and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine.