E. E. Mann, C. W. Palmer, S. Hagen
Sep 1, 1997
Citations
0
Influential Citations
4
Citations
Journal
Journal of Liquid Chromatography & Related Technologies
Abstract
Abstract Direct liquid chromatographic separation of 3R-trans, 3S-cis and 3R-cis 1,1-dimethylethyl (4R-cis)-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate enantiomers on a cellulose tris (3,5-dimethylphenyl carbamate) column is described. The 3R-cis isomer is an intermediate in the synthesis of atorvastatin (a HMG-CoA reductase inhibitor). The detection limit for each of the undesired 3R-trans and 3S-cis isomers was 0.2% by area percent normalization. The separation of the undesired 3S-trans diastereomer was occasionally observed, and was found to be greatly affected by slight differences in mobile phase composition.