K. Verma, S. Sanghi, Archana Jain
1988
Citations
0
Influential Citations
18
Citations
Journal
Journal of Chromatography A
Abstract
Abstract A pre-column reaction of bromide with 2-iodosobenzoic acid and acetanilide and reversed-phase high-performance liquid chromatography of the 4-bromoacetanilide formed has permitted sensitive, selective and accurate determination of bromide with the use of an UV detector. Employing 4-N-acetylaminotoluene as an internal standard, the method has been applied to determine bromide in natural and seawater, pharmaceutical formulations and blood. As low as 6 μg l −1 of bromide were assayed. Large amounts of ions such as chloride, nitrate, phosphate, ammonium sulphide, thiocyanate, sulphate, iodide, thiosulphate, cyanide and nitrite can be tolerated. The method is rapid, simple and precise, and has a limit of detection of 0.2 ng of bromide.