C. Vaccher, P. Berthelot, N. Flouquet
1991
Citations
0
Influential Citations
8
Citations
Journal
Journal of Chromatography A
Abstract
Abstract A liquid chromatography method was developed for the chiral resolution of [4-amino-3-(4-chlorophenyl)butyric acid isomers. The compound was derivatized in two steps: protection of the amino group with di- tert .-butyl carbonate and reaction with ( S )-α-methyl benzyl amine to obtain the diastereomeric mixture RS and SS . Chromatography was carried out on silica gel (5–20 μm) employing n -hexane—ethyl acetate as eluent. 1 H NMR spectroscopy and analytical high-performance liquid chromatography indicated that the separated fractions were pure.