G. Schmiedel, J. Filser, H. Bolt
Dec 1, 1983
Citations
1
Influential Citations
25
Citations
Quality indicators
Journal
Toxicology letters
Abstract
Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.