P. J. Chua, B. Tan, Xiaofei Zeng
Jul 15, 2009
Citations
0
Influential Citations
20
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Though many chiral amines such as l-proline and its derivatives have proven to be versatile catalysts in many reactions, L-prolinol was seldom used as organocatalyst for reactions. Herein, we report the first L-prolinol catalyzed asymmetric Michael addition of cyclohexanone to nitroolefins in the presence of benzoic acid to afford Michael adducts with high diastereoselectivities (87:13->99:1) and enantioselectivities (82-96%).