J. Cuppoletti, D. Malinowska, J. Chakrabarti
Apr 1, 2014
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Quality indicators
Journal
The FASEB Journal
Abstract
Objective. Lubiprostone is a bicyclic fatty acid (prostone) which is used widely for treatment of chronic idiopathic constipation (CIC), opioid‐induced constipation (OIC) and constipation‐associated irritable bowel syndrome (IBS‐C). [NAD+]‐15‐OH PGDH (PGDH), which synthesizes endogenous prostones from prostaglandins, is a suppressor of human gastrointestinal cancers and genetic therapy with PGDH slowed the growth of colon tumor xenographs. The present study was to determine whether lubiprostone, acting as a prostone, would slow growth of colon cancer cells which express low PGDH and whether transfection of low PGDH colon cancer cells with PGDH would ablate the effects of lubiprostone on the cancer cells.