Muge Qile, H. D. Beekman, D. Sprenkeler
Aug 30, 2019
Citations
0
Influential Citations
14
Citations
Journal
British Journal of Pharmacology
Abstract
Kv11.1 (hERG) channel blockade is an adverse effect of many drugs and lead compounds, associated with lethal cardiac arrhythmias. LUF7244 is a negative allosteric modulator/activator of Kv11.1 channels that inhibits early afterdepolarizations in vitro. We tested LUF7244 for antiarrhythmic efficacy and potential proarrhythmia in a dog model.