I. Skalpe, T. Torbergsen, P. Amundsen
Nov 1, 1973
Citations
0
Influential Citations
53
Citations
Journal
Acta Radiologica
Abstract
Three water-soluble contrast media are in present use for lumbar myelo graphy: methiodal sodium (Abrodil, Conturex, Myelotrast), meglumine io thalamate (Conray Meglumin) and meglumine iocarmate (Bis-Conray, Dimer-X). None of these media has gained general acceptance, mainly because of the irritative effects upon the nervous structures. Thus, although lumbar myelography with methiodal sodium has been performed at Ulleval Sykehus since 1947 in more than 4 500 patients with no serious complications, interest has now turned to metrizamide. This is a non-ionic water-soluble contrast medium for subarachnoid use which was synthetized in the research laboratories of Nyegaard & Co. (HOLTERMANN 1973). Extensive animal experiments reported in the present supplement indicate a marked reduction in the irritative effects of metrizamide compared with meglumine iocarmate. Clinical trials were therefore started in June 1972 to investigate the diagnostic properties of metrizamide in lumbar myelography and to search for any possible adverse effects.