M. Shimkin, R. Wieder, M. McDonough
Dec 1, 1969
Citations
1
Influential Citations
41
Citations
Quality indicators
Journal
Cancer research
Abstract
A series of 21 carbamates and 8 aziridines were compared for quantitative carcinogenic activity using the pulmonary tumor-induction method in Strain A mice for bioassay. Aziridines as a class were more active than the carbamates, with 3,4-dichlorophenyl- N -carbamoylaziridine being over 20 times more active on a molecular dose basis than urethan, the most active of the carbamates. Three carbamates ( N -hydroxyethyl, N -cyanoacetyl ethyl, and N -acetyl ethyl) approached the activity of ethyl carbamate. Methyl carbamate was completely inactive, suggesting an important role in carcinogenesis of the carboethoxy portion of the molecule. The pulmonary tumor response in Strain A mice is a rapid, reproducible, economic, quantitative bioassay for carcinogenic activity, and wider use of this method is recommended.