A. Rojanasakul, S. Nillius
1986
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Quality indicators
Journal
Journal of the Medical Association of Thailand = Chotmaihet thangphaet
Abstract
This article reviews research on the clinical use of luteinizing hormone-releasing hormone (LHRH) analogues for contraception. Inhibition of ovulation based on the paradoxical effect of chronic treatment with stimulatory analogues of LHRH has been the most extensively studied method female contraception. The intranasal approach to peptide contraception has been shown to provide safe effective and rapidly reversible contraception in women. LHRH has specific actions on the hypothalamic-pituitary-gonadal axis and is thus less likely to cause metabolic alterations and other systemic side effects than steroid contraceptive preparations. A new more potent LHRH superagonist nafarelin acetate is under clinical trial for female contraception and preliminary results in 30 women treated for 89 months are promising. Less effective and promising appear to be approaches aimed at interfering with the corpus luteum function. Also under investigation is the use of combined LHRH analogues and testosterone substitution for male contraception.