S. Al-Raqa, B. Köksoy, M. Durmuş
Feb 15, 2017
Citations
0
Influential Citations
5
Citations
Journal
Tetrahedron Letters
Abstract
Abstract In this study, the novel 4-(N,N′-dimethylamino)phenyl substituted lutetium(III) acetate phthalocyanine (2) and its quaternized derivative (3) were synthesized via a Suzuki-Miyaura coupling reaction between tetrakis(iodo) lutetium(III)acetate phthalocyanine (1) and 4-(N,N-dimethylamino)phenylboronic acid, and subsequent quaternization using dimethyl sulfate, respectively. The obtained phthalocyanine 3 exhibited excellent solubility in water which is important for photodynamic therapy applications. Photophysical properties such as fluorescence quantum yield and fluorescence lifetime, and photochemical properties such as singlet oxygen generation and photostability were investigated to determine their suitability for photodynamic therapy. The lutetium(III) phthalocyanines, especially quaternized derivative 3, showed promising properties as potential photosensitizers for the treatment of cancer, producing higher singlet oxygen (ΦΔ = 0.59) than motexafin lutetium (ΦΔ = 0.31) which is a clinically used lutetium texaphyrin photosensitizer.