Cuiyan Wu, Xiaojun Hu, Biao Gu
Feb 8, 2018
Citations
1
Influential Citations
14
Citations
Journal
Analytical Methods
Abstract
In this study, we developed a lysosome-targeting fluorescent probe, 3-(2,4-dinitrophenoxy)-2-(4-morpholinophenyl)-4H-chromen-4-one (DMC), for the detection of hydrogen sulfide (H2S) based on excited-state intramolecular proton transfer (ESIPT). Upon the treatment with H2S, a significant enhancement in the fluorescence was observed along with a distinct color change from yellow to colorless. This probe shows a low background spectroscopic signal, large Stokes shift, good sensitivity, and high selectivity towards H2S. Most importantly, DMC has low toxicity and excellent cell permeability, and could be applied to visualizing H2S in lysosomes.