K. Akaji, Y. Kiso
Jul 21, 1997
Citations
0
Influential Citations
34
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A novel intramolecular macrocyclization reaction on solid support using Heck reaction was achieved. The Heck coupling of acrylic acid amide to 3-iodobenzylamine on solid support proceeds smoothly to yield a cyclic tetrapeptide derivative containing a new 3-substituted cinnamic acid template and Arg-Gly-Asp sequence. The macrocyclization reaction takes place more rapidly on solid support than in solution.