Xinfang Duan, Ziling Ma, Fang Zhang
Jan 16, 2009
Citations
0
Influential Citations
40
Citations
Journal
The Journal of organic chemistry
Abstract
Iodo- or 2-bromopyridine N-oxides were readily magnesiated with i-PrMgCl x LiCl via the iodine or bromine-magnesium exchange. The bromine adjacent to pyridine N-oxide (at the 2- or 6-position) can be regioselectively magnesiated in the presence of other position substituted halogens. This method was tested in various substituted pyridine N-oxide systems, and has been successfully applied to the total synthesis of caerulomycins E and A.