J. Anker, R. Kopelman
Feb 10, 2003
Citations
3
Influential Citations
131
Citations
Quality indicators
Journal
Applied Physics Letters
Abstract
We have developed magnetically modulated optical nanoprobes (MagMOONs) to magnetically modulate the signal from fluorescent probes and thus separate it from autofluorescence, electronic offsets, and other background signals. These micro- and nanosized particles emit fluorescence signals, indicating chemical concentrations, and blink in response to rotating magnetic fields. Demodulating the signal dramatically enhances the probe’s signal to background ratio. The probes and methods promise to improve immunoassays, intracellular chemical sensing, and fundamental biochemical research.