W. B. Harrell, R. Doerge
Feb 1, 1967
Citations
0
Influential Citations
34
Citations
Journal
Journal of Pharmaceutical Sciences
Abstract
In a search for new therapeutic agents, a series of Mannich derivatives of 3-methyl-2-phenylindolizine and 3-ethyl-2-phenylindolizine has been prepared. The mechanism by which 2,3-disubstituted indolizines participate in the Mannich reaction has been examined and alternate SN 1 and SN 2 routes have been proposed. 1-Diethyl-aminomethyl-3-methyl-2-phenylindolizine has been tested and found to have central nervous system depressant activity.