C. Bradham, D. McClay
Apr 10, 2006
Citations
2
Influential Citations
212
Citations
Quality indicators
Journal
Cell Cycle
Abstract
p38 is a MAPK that has been shown to induce a wide variety of biological effects in cell culture,in response to a wide range of stimuli. These effects are dependent not only on the stimuli, butalso on the cellular context, resulting in a bewildering array of possibilites1. For example, p38was shown to induce apoptosis in some cells, but prevent apoptosis in others2. Similarly opposedeffects had been observed with respect to cell cycle regulation2. The role of p38 in inflammatorydisease has been appreciated from the beginning, since it was initially identified as an cytokineinducer3. More recently, p38 function has been evaluated in vivo, and through these studies p38has emerged as an important regulator of both embryonic development and cancer progression.This review will focus on these in vivo studies in an effort to provide perspective on p38biologically and as a pharmacological target.