M. Kondo, T. Oishi, K. Ishifuji
Apr 1, 1973
Citations
0
Influential Citations
6
Citations
Journal
The Journal of antibiotics
Abstract
Maridomycin has been found to have a strong in vitro antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria such as Neisseria gonorrhoeae and Vibrio cholerae. The antibiotic was more active at pH9than pH6. The antibacterial activity was enhanced by decrease in bacterial inoculum size, but not influenced by the presence of horse serum. The m vitro bacterial resistance to maridomycinwas enhanced stepwise by serial transfer, and cross resistance was observed between maridomycinand each of macrolide antibiotics tested. This antibiotic, however, was effective against clinically isolated macrolide-resistant group B and C staphylococci. Furthermore, maridomycin demonstrated bacteriostatic activity and its protein binding ratio examined by cellophane bag dialysis method was found to be low. Maridomycinwas as effective as leucomycin on Gram-positive bacterial infection in mice by subcutaneous, intraperitoneal or intravenous administration.