Marie-France Moreau, D. Parry, Martine Bayle
Aug 1, 1995
Citations
0
Influential Citations
3
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
N-(2-diethylaminoethyl)-4-iodobenzamide (I) and N-(3-dimethylaminopropyl)-4-iodobenzamide (11), recently developed in our laboratory, are promising agents for metastatic melanoma detection in nuclear medicine. In order to study their in vivo metabolism, we labelled them with carbon-14 and carbon-13 on two sites : on the carbonyl group (la, lla), and on the dialkylaminoalkyl moiety (Ib, IIb).The overall yields calculated from sodium [ 14 C] or [ 13 C] cyanide used as precursor are in the range of 55 % for Ia, IIa, llb, and 21 % for Ib.