B. Middleditch, P. Vouros, C. Brooks
Feb 1, 1973
Citations
0
Influential Citations
31
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
Certain steroid drugs, their metabolites, and related model compounds which possess a 17‐hydroxy group can be converted to trimethylsilyl ethers which give characteristic ions of type [128 + R]+in their mass spectra, where R is the mass of the other 17‐substituent. Extensive deuterium labelling studies are carried out to verify the modes of formation of these and related ions which are of diagnostic value in analytical work.