M. V. Bidevkina, M. I. Golubeva, G. P. Pankratova
Aug 28, 2019
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Journal
Toxicological Review
Abstract
Pentyl chloroformate refers to moderately toxic substances when administered in the stomach (DL 50 for white mice 1000,0 ± 86,0 mg/kg), has a pronounced irritant effect on the skin and mucous membrane of the eyes, has no skin-resorptive and sensitizing effect, weakly accumulates in the body. It shows selective irritant effect on the respiratory system on inhalation. The irritant threshold for rats is 7,8 mg/m3, for humans - 2,3 mg/m 3 . Hygienic standards for pentyl chloroformate are recommended for approval: MAC in the air of the working area - 0,5 mg/m 3 (vapors, hazard class 2, marked «requires special protection for the skin and eyes»); tentative safe exposure level in the atmospheric air of populated areas - 0,005 mg/m 3 .