Jiabei Wang, T. Zheng, Xi Chen
Feb 1, 2011
Citations
1
Influential Citations
36
Citations
Quality indicators
Journal
Journal of Gastroenterology and Hepatology
Abstract
Background and Aims: Nutlin‐3, a selective small‐molecule inhibitor of the p53‐MDM2 interaction, has been shown to have antitumor activities in various tumors with wild‐type p53. However, its effect on hepatocellular carcinoma (HCC) with different types of p53 remains unclear. This study is designed to determine nutlin‐3′s antitumor efficacy and underlying mechanisms of action in human HCC cells.