R. Wilson, D. Sykes, D. Watson
Sep 1, 1988
Citations
13
Influential Citations
347
Citations
Quality indicators
Journal
Infection and Immunity
Abstract
The phenazine pigments pyocyanin and 1-hydroxyphenazine were resolved by high-pressure liquid chromatography from the sputum sol phase from 9 of 13 patients with cystic fibrosis or bronchiectasis colonized by Pseudomonas aeruginosa. The concentrations measured were each sufficient to inhibit ciliary beating in vitro and contributed a significant proportion of sol phase toxicity for respiratory epithelium.