A. Fedorov, S. El'-Karadagi, V. A. Rusiaev
Jul 1, 1988
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Journal
Voprosy virusologii
Abstract
The interaction of 2-(1'-aminoethyl)-bicyclo (2.2.1) heptane hydrochloride possessing anti-influenza activity with flat bilayer lipid membranes was studied. The compound was shown to adsorb and build-in into the lipid bilayer changing the charge, modulus of transverse elasticity, and ion permeability of the membranes. Pre-addition of the preparation into the medium washing the membrane prevents interaction of influenza virus matrix protein with the membrane. The compound also destroys M-protein aggregates in the aqueous phase. The possible role of the observed effect of the compound in its antiviral action is discussed.