A. Michel, S. Ng, S. Roman
Apr 1, 2009
Citations
1
Influential Citations
58
Citations
Journal
British Journal of Pharmacology
Abstract
Background and purpose: AZ11645373 and N‐{2‐methyl‐5‐[(1R, 5S)‐9‐oxa‐3,7‐diazabicyclo[3.3.1]non‐3‐ylcarbonyl]phenyl}‐2‐tricyclo[3.3.1.13,7]dec‐1‐ylacetamide hydrochloride (compound‐22) are recently described P2X7 receptor antagonists. In this study we have further characterized these compounds to determine their mechanism of action and interaction with other species orthologues.