Z. Bin
2008
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0
Influential Citations
1
Citations
Quality indicators
Journal
Journal of Medical Postgraduates
Abstract
Objective:To study the effect of dracorhodin perchlorate on preventing and treating renal injury in diabetic nephropathy(DN).Methods:8 weeks old C57BL/6 male mice were randomly divided into six groups:normal control group,DN model group,insulin control group(DN mice were administered by insulin),dracorhodin perchlorate groups(DN mice were administered of dracorhodin perchlorate at 20,10,and 5 mg/(kg·d).DN mice was induced by streptozotocin(STZ) 150 mg/(kg·d) peritoneal injection.The mice were sacrificed at the end of the 4th week.The metabolic data were measured at 4th week.The mRNA expression of Serum and glucocorticoid induced kinase 1(SGK1),transforming growth factor-β1(TGF-β1) and fibronectin(FN) were detected by RT-PCR.Renal function was evaluated by serum creatinine clear rate.Result;Dracorhodin perchlorate and insulin can reduce significantly the expression of SGK1,TGF-β1,FN and extracellular matrix(ECM) in kidney,and decrease significantly GFR(glomerular filtration rate) and proteinuria,and the reduction is dose-dependent on dracorhodin perchlorate treatment.Conclusion:Dracorhodin perchlorate can prevent and treat renal injury in diabetic nephropathy mice,and the mechanism may be related with the decrease of SGK1,TGF-β1 and FN mRNA in renal cortex.