Ying-chun Liang
2009
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Chinese Traditional and Herbal Drugs
Abstract
Objective To approach the antiasthmatic mechanism of peimisine in Fritillaria monatha.Methods To observe the effect of peimisine in the different concentration on the tracheal smooth muscle contraction in vitro organ induced by Ach,His,β-receptor,CaCl2,Pro,in nitricoxide synthase catastaltica.Results Peimisine(0.046 and 0.092 mmol/L) made the EC50 induced by Ach increased;The EC50 of peimsine(0.092 mmol/L) was not changed by His;The EC50 of peimisine(0.092 mmol/L) was not significantly different to tracheal smooth muscle contraction induced by CaCl2;Three dosages of peimisine had significant inhibition on the release of intracellular calcium induced by CaCl2(P0.05,0.01,and 0.001) in a dose-dependent manner.But extracellular calcium influx was not significantly inhibited.Comparing with the L-NAME+dissolvant group,three dosages of peimisine couldn′t restrain the contraction and had no significant difference.Conclusion Peimisine could affect M-receptor,excit β-receptor,restrain the release of internal calcium,and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma.