Sylvain Taillemaud, Nicolas Diercxsens, A. Gagnon
Nov 16, 2015
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Influential Citations
19
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Journal
Angewandte Chemie
Abstract
A stereoselective bromocyclopropanation of allylic alcohols using dibromomethylzinc bromide is described. Spectroscopic studies to monitor the formation of transient intermediates not only led to the development of a more-atom-economical halocyclopropanation reaction, but also highlighted the unique role of ether additives in the process. The desired bromo-substituted cyclopropanes were isolated in high yields and excellent diastereo- as well as enantioselectivities using readily available reagents.