Yingke Zhao, Yue Liu, Keji Chen
Sep 7, 2016
Citations
0
Influential Citations
83
Citations
Quality indicators
Journal
Oxidative Medicine and Cellular Longevity
Abstract
Tetramethylpyrazine, a natural compound from Ligusticum wallichii (Chuan Xiong), has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystems, especially in cardiovascular, its pharmacological action, clinical application, and the structural modification have attracted broad attention. In this paper its mechanisms of action, the clinical status, and synthetic derivatives will be reviewed briefly.