Hirai Shinichiro, Y. Takatsuka, Mima Hiroyuki
Aug 1, 1981
Citations
2
Influential Citations
233
Citations
Quality indicators
Journal
International Journal of Pharmaceutics
Abstract
Abstract The mechanisms of the promoting effect of surfactants on the nasal absorption of insulin was investigated in rats. The promoting effect of several non-ionic surfactants, sodium lauryl sulfate and saponin, were paralleled by their abilities to lyze the rabbit erythrocyte and to release protein from the nasal mucosa, whereas the promoting effect of bile acid salts was attributed not only to their direct effect on the nasal mucosa, but also to their inhibitory effect on proteolytic enzymes. Mucosal alterations, observed by scanning electron microscopy, were reversible and the membrane was relatively rapidly restored. Bile acid salts were found to be less irritative to the nasal mucosa than non-ionic ether type surfactants.