P. V. D. Wetering, N. Zuidam, M. J. Steenbergen
Oct 28, 1998
Citations
4
Influential Citations
267
Citations
Quality indicators
Journal
Macromolecules
Abstract
The hydrolytic stability of poly(2-(dimethylamino)ethyl methacrylate) was investigated and compared with the stability of its monomer 2-(dimethylamino)ethyl methacrylate (DMAEMA), with 2-(dimethylamino)ethyl isobutyrate (DMAEIB), representing the repeating unit in the polymer, and with the related 3-(dimethylamino)propyl methacrylate (DMAPMA) (H0/pH range −0.5 to +12, at 37 °C, in aqueous solution). At pH pKa) no differences in stability between the compounds were found. P(DMAEMA), either in its free form or complexed to DNA, was substantially more stable to hydrolytic degradation than DMAEMA and DMAEIB. Fluorescence measurements performed with a copo...