Davin Tan, Vjekoslav Štrukil, C. Mottillo
Apr 22, 2014
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Influential Citations
77
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Quality indicators
Journal
Chemical communications
Abstract
We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates.