Cheng-Kwei Wu, Xiaoqin Bian, Lizhong Wang
Aug 7, 2022
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Journal
Synthesis
Abstract
An efficient protocol for the synthesis of 2-aryl-5-benzylpyrimidine-4,6-diamines from readily available substituted 2-benzylidenemalononitriles and substituted benzamidines was developed. This practical protocol provided high value pyrimidine-4,6-diamines in moderate to good yields under simple reaction conditions. This approach also enables some modifications of structurally complex bioactive molecules which exhibits potential applications in medicinal chemistry.