R. Raju, K. Maram, K. Anitha
Dec 7, 2022
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Journal
Letters in Organic Chemistry
Abstract
A series of N-(furan/thiophene/pyrrole-2-yl-(2-hydroxynaphthalen-1-yl)methyl)acetamide derivatives 4 has been depicted by one-pot three-component synthesis using 2-naphthol 1 with aldehydes 2 and amides 3 in the presence of DBU as a catalyst in ethanol as solvent under reflux condition for 110-120 min. This method has the advantages of good yields, being environmentally friendly, straightforward protocol, short reaction times, and mild reaction conditions.